Vol 21, No 1 (2017) > MJT Topical Conference on Technology >

Encapsulation Process of Propolis Extract by Casein Micelle Improves Sunscreen Activity

Muhamad Sahlan 1 , Dara Dienayati 1 , Darul Hamdi 1 , Soraya Zahra 1 , Heri Hermansyah 1 , Malyn Chulasiri 2


  1. Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia
  2. Departments of Microbiology and Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand


Abstract: Propolis, a wax bee glue, have antioxidant activity and effective as broad spectrum UVB and UVA photoprotection
sunscreens agent. To improve photoprotection activity in sunscreen cream, the propolis was encapsulated by casein
micelle. The Indonesian propolis was extracted by ethanol and separated the wax by freeze precipitation. The extract
was encapsulated by casein and reduced their size by ball mill homogenizer with the encapsulation efficiency about
80% and size of particles about 80 nm. The particles was applied in sunscreen cream, evaluate their stabillity and
photoprotection activity Sun Protection Factor (SPF) spectrophotometer (Optometric 290s). The results shows that the selected creams were stable and have moderate photoprotection activities higher than the controls. The encapsulation process of propolis by casein micelle can improve their photoprotection activity.
Keywords: propolis, encapsulation, casein, photoprotection
Published at: Vol 21, No 1 (2017) pages: 1-6

Access Counter: 29 views, 16 PDF downloads, .

Full PDF Download


A. Salatino, E.W. Teixeira, G. Negri, D. Message, Evid. Based Complement Alternat. Med. 2 (2005) 33.

M.C. Marcucci, Apidologie 26 (1995) 83.

G.A. Burdock, Food Chem. Toxicol. 36 (1998) 347.

A.H. Banskota, Y. Tezuka, S. Kadota, Phytother. Res. 15 (2001) 561.

A. Sabir, Dent. J. 38 (2005) 135.

A. Sabir, Dent. J. 38 (2005) 77.

M. Gonzalez, G. Bernardo, R. Roxana, R. Elida, M. Maria, Am. J. Pharm. 22(3) (2003) 243.

L. Chen, G.E. Remondetto, M. Subirade, Trends in Food Sci. Tech. 17 (2006) 272.

A. Madene, M. Jacquot, J. Scher, S. Desobry, Int. J. Food Sci. Tech. 41 (2006) 1.

M. Sahlan, T. Supardi, Int. J. Pharm. Bio. Sci. 4 (2013) 297.

K. Ghasemi, Y. Ghasemi, M.A. Ebrahimzadeh, Pak. J. Pharm. Sci. 22 (2009) 277.

J.R. Villalobos-Hernandez, C.C. Muller-Goymann, Eur. J. Pharm. Biopharm. 60 (2005) 113.

Y.W. Park, M. Juarez, M. Ramos, G.F.W. Haenlein, Small Ruminant Res. 68 (2007) 88.

A. Sahu, N. Kasoju, U. Bora, Biomacromo Lecules 9 (2008) 2905.

E. Semo, K. Ellina, D. Dganit, Y.D. Livney. Food Hydrocolloids 21 (2007) 936.

V.J. Mohanraj, Y. Chen. Tropical J. Pharm. Res. 5 (2006) 561.

M. Ichihashi, M. Ueda, A. Budiyanto, T. Bito, M. Oka, M. Fukunaga, K. Tsuru, T. Horikawa. Toxicology 189 (2003) 21.